BTK C481 Resistance Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the cysteine at position 481 of the tyrosine-protein kinase BTK protein to another amino acid that confers resistance to pharmacological inhibitors targeting BTK activity, such as ibrutinib.

**Synonyms:** - BTK C481X Resistance Mutation - BTK Cys481 Resistance Mutation - BTK Cys481Xxx Resistance Mutation - BTK NP_000052.1:p.C481X Resistance Mutation - BTK NP_000052.1:p.Cys481Xxx Resistance Mutation - BTK p.C481X Resistance Mutation - BTK p.Cys481Xxx Resistance Mutation - Bruton Tyrosine Kinase C481 Resistance Mutation - Bruton Tyrosine Kinase Cys481 Resistance Mutation - Cys481 Resistant Mutation - Cysteine-481 BTK Resistance Mutation - Tyrosine-Protein Kinase BTK C481 Resistance Mutation - Tyrosine-Protein Kinase BTK Cys481 Resistance Mutation