T-Cell Receptor Alpha-Beta

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Receptor

**Definition:** A heterodimeric complex comprised of the highly variable T-cell receptor (TCR) alpha and beta chain proteins, which are linked by interchain disulfide bonds. This membrane bound complex is expressed on the surface of most T-lymphocytes and is involved in the recognition of peptide antigens that are presented by major histocompatibility (MHC) proteins. The alpha/beta dimer is non-covalently associated with the CD3 complex, which promotes ligand-dependent signaling.

**Synonyms:** - Alpha-Beta TCR - Alpha-Beta-TCR - Alpha/Beta TCR - T-Cell Receptor Alpha Beta - T-Cell Receptor Alpha/Beta - T-Cell Receptor, Alpha-Beta - TCR Alpha-Beta - TCR Alpha/Beta