Misitatug Blivedotin

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of an antibody directed against the human cell surface glycoprotein mesothelin and conjugated, via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of misitatug blivedotin, the antibody moiety targets and binds to the tumor associated antigen (TAA) mesothelin on the surface of tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in mesothelin-expressing tumor cells. Mesothelin is overexpressed by all mesotheliomas and a variety of other cancers, while it is minimally expressed in normal tissue.

**Synonyms:** - ADC RC88 - Anti-mesothelin Antibody-drug Conjugate RC88 - Anti-mesothelin/MMAE ADC RC88 - Anti-mesothelin/MMAE Antibody-drug Conjugate RC88 - MISITATUG BLIVEDOTIN - RC 88 - RC-88 - RC88