Allogeneic Anti-CD20 CAR T-cells LUCAR-20S

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of donor-derived T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20 CAR T-cells LUCAR-20S specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies.

**Synonyms:** - LUCAR 20S - LUCAR-20S - LUCAR-20S CAR-T Cells - LUCAR20S