MCL-1 Inhibitor ABBV-467

**Semantic type:** Pharmacologic Substance

**Definition:** An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor ABBV-467 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.

**Synonyms:** - ABBV 467 - ABBV-467 - ABBV-467 - ABBV467 - Myeloid Cell Leukemia-1 Inhibitor ABBV-467