JUN Family Gene

**Semantic type:** Gene or Genome

**Definition:** JUN Family Genes encode nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) that can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI)

**Synonyms:** - JUN Genes - JUN Proto-oncogene Family