Aspirin/Dipyridamole

**Semantic type:** Pharmacologic Substance

**Definition:** A fixed combination of aspirin, a cyclooxygenase inhibitor, and dipyridamole, a phosphodiesterase (PDE) inhibitor, with antiplatelet and antithrombotic activities. Upon oral administration of aspirin/dipyridamole, aspirin binds to and irreversibly inhibits platelet cyclooxygenase, thereby inhibiting thromboxane A2 formation. This prevents platelet aggregation and vasoconstriction. Dipyridamole inhibits adenosine uptake by platelets and endothelial cells, triggering an accumulation of cyclic adenosine monophosphate (cAMP), and inhibiting the stimulation of platelet aggregation by agents such as platelet activating factor and collagen.

**Synonyms:** - Aggrenox - Aspirin and Dipyridamole - Aspirin and dipyridamole - Aspirin-Dipyridamole - Dipyridamole-Aspirin - Dipyridamole/Aspirin