Amcenestrant

**Semantic type:** Pharmacologic Substance

**Definition:** An orally available, nonsteroidal selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, amcenestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.

**Synonyms:** - AMCENESTRANT - SAR 439859 - SAR-439859 - SAR439859 - Selective Estrogen Receptor Degrader SAR439859 - Selective Estrogen Receptor Downregulator SAR439859