Zedenoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) cellular preparation composed of T-lymphocytes specifically reactive to the four tumor-associated antigens (TAAs) human Wilms tumor protein-1 (WT1), preferentially expressed antigen in melanoma (PRAME), the cancer-testis antigen NY-ESO-1, and survivin, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, zedenoleucel recognizes and kills cancer cells expressing these TAAs. WT1, NY-ESO-1, PRAME, and survivin are expressed on certain tumor cell types and play key roles in tumor cell proliferation and survival.

**Synonyms:** - Allogeneic MultiTAA-specific T-lymphocytes MT-401 - Donor-Derived Multi-Tumor-Associated Antigen-specific T Cells - MT 401 - MT-401 - MT-401-OTS - MT401 - ZEDENOLEUCEL - Zelenoleucel