Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers.

**Synonyms:** - Anti-LeB/LeY Monoclonal Antibody GNX102 - Anti-branched Lewis B/Lewis Y Monoclonal Antibody GNX102 - GNX 102 - GNX-102 - GNX102