Lymphodepleted Autologous CD4-directed CAR T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the T-cell surface antigen CD4, administered with lymphodepletion, with potential immunostimulating and antineoplastic activities. Upon administration, lymphodepleted autologous CD4-directed CAR T cells specifically recognize and kill CD4-expressing tumor cells. CD4, a tumor-associated antigen (TAA), is overexpressed in various lymphomas, including peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma.

**Synonyms:** - Autologous LCAR-T2C CAR-T Cells - Autologous LCAR-T2C CAR-T-lymphocytes