Polysulfated Glycosaminoglycan

**Semantic type:** Pharmacologic Substance

**Definition:** A semi-synthetic glycosaminoglycan (GAG) prepared by extracting GAGs from bovine tracheal cartilage and consisting of mostly chondroitin sulfate, with anti-arthritic activities in animals including dogs. Upon administration, polysulfated GAG (PSGAG), a proteolytic enzyme inhibitor, may inhibit various processes that lead to the loss of cartilaginous mucopolysaccharides. This may include the inhibition of interleukin-1 (IL-1)-mediated inflammation and degradation of cartilage proteoglycans and collagen. PSGAG may also stimulate the synthesis of protein, collagen, proteoglycans, and hyaluronic acid, which may improve joint function.

**Synonyms:** - Adequan Canine - POLYSULFATED GLYCOSAMINOGLYCAN - PSGAG