NLR Family CARD Domain-Containing Protein 4

**Semantic type:** Immunologic Factor

**Definition:** NLR family CARD domain-containing protein 4 (1024 aa, ~116 kDa) is encoded by the human NLRC4 gene. This protein is involved in the positive regulation of caspase activation, cytokine expression and pyroptosis of macrophages.

**Synonyms:** - CARD, LRR, And NACHT-Containing Protein - Caspase Recruitment Domain-Containing Protein 12 - Clan Protein - ICE-Protease Activating Factor - Ice Protease-Activating Factor - Ipaf - NLRC4