Autogene Cevumeran

**Semantic type:** Pharmacologic Substance

**Definition:** An mRNA-based individualized, therapeutic cancer vaccine targeting an unspecified amount of tumor-associated antigens (TAAs) that are specifically expressed in the patient's cancer, with potential immunostimulatory and antineoplastic activities. Upon administration, autogene cevumeran is taken up and translated by antigen presenting cells (APCs) and the expressed protein is presented via major histocompatibility complex (MHC) molecules on the surface of the APCs. This leads to an induction of both cytotoxic T-lymphocyte (CTL)- and memory T-cell-dependent immune responses against cancer cells expressing the TAA(s).

**Synonyms:** - AUTOGENE CEVUMERAN - BNT 122 - BNT-122 - BNT122 - PCV RO7198457 - Personalized Cancer Vaccine RO7198457 - RG 6180 - RO 7198457 - RO-7198457 - RO7198457