Rezvilutamide

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable androgen receptor (AR) antagonist with potential antineoplastic activity. Upon administration, rezvilutamide competitively binds to AR in target tissues, which both prevents androgen-induced receptor activation and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of cell growth of AR-expressing tumor cells. ARs are overexpressed in prostate cancer and play a key role in prostate cancer cell proliferation.

**Synonyms:** - Androgen Receptor Antagonist SHR3680 - REZVILUTAMIDE - SHR 3680 - SHR-3680 - SHR3680