TLR7 Agonist JNJ-64794964

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally bioavailable Toll-like receptor (TLR) 7 agonist, with potential immunostimulating, antiviral and antitumor activities. Upon oral administration, TLR7 agonist JNJ-64794964 specifically targets, binds to and activates TLR7. This triggers anti-viral and anti-tumor activities through the activation of cluster of differentiation (CD) 8-positive T cells, B cells, and innate immune cells including natural killer (NK) cells and macrophages, secretion of interferon alpha (IFNa), and the production of various pro-inflammatory and anti-inflammatory cytokines. TLR7 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

**Synonyms:** - AL 034 - AL-034 - AL034 - JNJ 4964 - JNJ 64794964 - JNJ-4964 - JNJ-64794964 - JNJ4964 - JNJ64794964 - TQ A3334 - TQ-A3334 - TQA3334 - Toll-like Receptor 7 Agonist AL-034