COVID-19 Vaccine V591

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** A coronavirus vaccine based on a measles virus (MV) vector expressing the spike (S) protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with potential immunomodulating and anti-COVID-19 activities. Upon intramuscular administration of the COVID-19 vaccine V591, the MV infects human cells, which produces SARS-CoV-2 S protein. The released S protein activates the immune system to induce a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus.

**Synonyms:** - MV-encoding SARS-CoV-2 Spike Protein Vaccine - SARS-CoV-2 Vaccine V591 - TMV 083 - TMV-083 - TMV083 - V 591 - V-591 - V591