Immunodeficiency with Hyper-IgM, Type 3

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal recessive subtype of immunodeficiency with hyper-IgM caused by mutation(s) in the CD40 gene, encoding tumor necrosis factor receptor superfamily member 5.

**Synonyms:** - CD40 Deficiency - CD40 deficiency - HIGM3