GFI1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GFI1 wild-type allele is located in the vicinity of 1p22.1 and is approximately 14 kb in length. This allele, which encodes zinc finger protein Gfi-1, plays a role in transcriptional repression during multilineage blood cell development. Mutation of the gene is associated with autosomal recessive severe congenital neutropenia 2 (SCN2) and adult nonimmune chronic idiopathic neutropenia.

**Synonyms:** - GFI-1 - GFI1A - Growth Factor Independence-1 Gene - Growth Factor Independent 1 Gene - Growth Factor Independent 1 Transcription Repressor Gene - Growth Factor Independent 1 Transcriptional Repressor wt Allele - Growth Factor-Independent 1 Gene - SCN2 - ZNF163