LRRC8A wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human LRRC8A wild-type allele is located in the vicinity of 9q34.11 and is approximately 36 kb in length. This allele, which encodes volume-regulated anion channel subunit LRRC8A protein, plays a role in cellular homeostasis. Mutation of the gene is associated with autosomal dominant non-Bruton type agammaglobulinemia (agammaglobulinemia 5).

**Synonyms:** - AGM5 - FLJ10337 - KIAA1437 - LRRC8 - Leucine Rich Repeat Containing 8 Family Member A Gene - Leucine Rich Repeat Containing 8 Gene - Leucine Rich Repeat Containing 8 VRAC Subunit A wt Allele - SWELL1