Autologous Tolerogenic Proinsulin Peptide-loaded Dendritic Cells PIpepTolDC

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A vaccine composed of autologous tolerogenic dendritic cells (DCs) loaded with the beta cell protein proinsulin peptide (PIpep), C19-A3, with potential immunosuppressive and immune-regulating activities. Upon intradermal administration, the autologous tolerogenic PIpep-loaded DCs may induce proinsulin-specific regulatory T-cells (Tregs). This may suppress the autoimmune destruction of the insulin-producing beta cells, thereby protecting the beta cells.

**Synonyms:** - Autologous Tolerogenic DC with Proinsulin Peptide PIpepTolDC - Autologous Tolerogenic PIpep-loaded Dendritic Cells PIpepTolDC - PIpepTolDC - PIpepTolDC Vaccine - Proinsulin-loaded Tolerogenic DCs PIpepTolDC - Tolerogenic DC Vaccine PIpepTolDC