CHEK2-Related Hereditary Cancer Predisposition Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal dominant cancer predisposition syndrome caused by germline mutations of the CHEK2 gene. It is associated with breast carcinoma, gastric carcinoma, colorectal carcinoma, thyroid gland carcinoma, kidney carcinoma, prostate carcinoma, and non-Hodgkin lymphoma.

**Synonyms:** - CHEK2-Associated Cancer Predisposition - CHEK2-Associated Li-Fraumeni-Like Syndrome - CHEK2-Related Hereditary (Breast) Cancer Predisposition Syndrome - Li-Fraumeni Syndrome 2 - Li-Fraumeni Syndrome, CHEK2-Associated - Li-Fraumeni-Like Syndrome