Immunodeficiency 11B with Atopic Dermatitis

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal dominant condition caused by mutation(s) in the CARD11 gene, encoding caspase recruitment domain-containing protein 11. It is characterized by the onset of moderate to severe atopic dermatitis in early childhood, defects in T-cell activation, increased IgE, and eosinophilia.

**Synonyms:** - Atopic Dermatitis, Elevated IgE, and Eosinophilia - CARD11/CID - IMD11B