YAP1 Antisense Oligonucleotide ION537

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** An antisense oligonucleotide (ASO) targeting the transcription coactivator yes-associated protein 1 (YAP1), with potential antineoplastic activity. Upon administration, YAP1 ASO ION537 targets and binds to messenger RNA (mRNA) for YAP1, thereby inhibiting translation of YAP1. Suppression of YAP1 expression prevents the binding of YAP1 to transcription factors, thereby inhibiting gene transcription involved in tumor cell proliferation and survival. The Hippo/YAP1 pathway is dysregulated in certain cancers, resulting in constitutive YAP1 activation.

**Synonyms:** - ION 537 - ION-537 - ION537 - YAP1 ASO ION537