CXCR2 Agonist MGTA-145

**Semantic type:** Pharmacologic Substance

**Definition:** An agonist of CXC chemokine receptor type 2 (CXCR2), with potential hematopoietic stem cell (HSC) mobilization activity. Upon administration, CXCR2 agonist MGTA-145 binds to and activates CXCR2. This releases matrix metalloproteinase-9 (MMP-9), resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. The HSCs can be collected for autologous and allogeneic stem cell transplantation.

**Synonyms:** - GRO-beta - GROb - MGTA 145 - MGTA-145 - MGTA145