Goflikicept

**Semantic type:** Pharmacologic Substance

**Definition:** A heterodimeric fusion protein comprised of the extracellular portions of human interleukin (IL)-1 receptor type 1 (IL-1R1) and IL-1 receptor accessory protein (IL-1RAcP) linked to a mutant Fc portion of human immunoglobulin G1 (IgG1), with potential anti-inflammatory activity. Upon administration, goflikicept targets and binds to the proinflammatory cytokine IL-1 beta (IL-1b) and prevents the binding of IL-1b to the IL-1 receptor. This inhibits IL-1b-mediated signaling pathways, and suppresses inflammatory responses mediated by IL-1b. IL-1b plays a key role in inflammation, which is present in various disease states.

**Synonyms:** - GOFLIKICEPT - RPH 104 - RPH-104 - RPH104