Eclitasertib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, small-molecule inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1), with potential anti-inflammatory and immunomodulatory activities. Upon oral administration, eclitasertib disrupts RIPK1-mediated signaling, and may attenuate inflammation and the resulting tissue damage. RIPK1, a signaling protein in the tumor necrosis factor (TNF) receptor pathway, plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition.

**Synonyms:** - DNL 758 - DNL-758 - DNL758 - ECLITASERTIB - SAR 443122 - SAR-443122 - SAR443122