Zirconium Zr 89-ss-Pertuzumab

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A radioimmunoconjugate composed of pertuzumab, a humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the tyrosine kinase receptor human epidermal growth factor-2 (HER2; HER-2), and linked, using a site-specific bioconjugation method, to the radioisotope zirconium Zr 89 (Zr89), with potential use in the imaging of HER-2-expressing tumor cells upon positron emission tomography (PET). Upon administration of zirconium Zr 89-ss-pertuzumab, the pertuzumab moiety targets and binds to HER-2. After binding and internalization into HER-2-expressing tumor cells, Zr89 facilitates the visualization and detection of HER-2-expressing tumor cells using PET. This assesses HER2-expression and may predict or evaluate the tumor's response to certain HER-2-targeting chemotherapeutics. Site-specific bioconjugation may produce better defined and more homogeneous radioimmunoconjugates.

**Synonyms:** - 89Zr-ss-Pertuzumab - Site-specifically Labeled 89Zr-Pertuzumab - Zr 89-ss-Pertuzumab