HPD wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HPD wild-type allele is located in the vicinity of 12q24.31 and is approximately 49 kb in length. This allele, which encodes 4-hydroxyphenylpyruvate dioxygenase protein, plays a role in the degradation of tyrosine. Mutation of the gene is associated with tyrosinemia type 3 and hawkinsinuria.

**Synonyms:** - 4-HPPD - 4-Hydroxyphenylpyruvate Dioxygenase wt Allele - 4HPPD - GLOD3 - HPPDASE - PPD