CDH11/USP6 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(16;17)(q22;p13) which fuses the upstream promoter sequences for the CDH11 gene upstream of the entire coding region of the USP6 gene. This rearrangement is associated with myositis ossificans, fibro-osseous pseudotumor of digits, and aneurysmal bone cyst and expression of this fusion gene results in overexpression of the ubiquitin carboxyl-terminal hydrolase 6 protein.

**Synonyms:** - CDH11-TRE17 Fusion Gene - CDH11-USP6 Fusion Gene - CDH11/TRE17 Fusion Gene - CDH11::USP6 Fusion Gene - Cadherin 11-Ubiquitin Specific Peptidase 6 Fusion Gene - Cadherin 11/Ubiquitin Specific Peptidase 6 Fusion Gene