Anti-TYRP1/CD3 T-cell Engager RO7293583

**Semantic type:** Pharmacologic Substance

**Definition:** A bispecific T-cell engager directed against the tumor-associated antigen (TAA) tyrosinase-related protein 1 (TYRP1; TRP1; glycoprotein 75; gp75) and the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, anti-TYRP1/CD3 T-cell engager RO7293583 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and TYRP1 found on TYRP1-expressing tumor cells. This activates and redirects CTLs to TYRP1-expressing tumor cells, which results in the CTL-mediated death of TYRP1-expressing tumor cells. TYRP1, a transmembrane glycoprotein, is involved in melanin biosynthesis and is expressed in melanosomes of human melanocytes and melanomas.

**Synonyms:** - Anti-TRP1/CD3 T-cell Engager RO7293583 - Anti-gp75/CD3 T-cell Engager RO7293583 - RO 7293583 - RO-7293583 - RO7293583 - TYRP1-targeting CD3 T-cell Engager RO7293583