Multidrug Resistance Process

**Semantic type:** Phenomenon or Process

**Definition:** Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.

**Synonyms:** - MDR - MULTIPLE DRUG RESISTANCE - Multiple Drug Resistance - multidrug resistance