SERPINE1/FOSB Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(7;19)(q22;q13) which fuses non-coding exon 1 of the SERPINE1 gene with exon 1 or 2 of the FOSB gene. This rearrangement is associated with pseudomyogenic hemangioendothelioma and expression of this fusion gene results in overexpression of protein FosB.

**Synonyms:** - SERPINE1-FOSB Fusion Gene - SERPINE1::FOSB Fusion Gene - Serpin Family E Member 1-FosB Proto-Oncogene Fusion Gene - Serpin Family E Member 1/FosB Proto-Oncogene Fusion Gene