ACTB/FOSB Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(7;19)(p22;q13) which fuses exon 3 of the ACTB gene with exon 2 of the FOSB gene. This rearrangement is associated with pseudomyogenic hemangioendothelioma and deregulation of protein fosB transcriptional activation activity.

**Synonyms:** - ACTB-FOSB Fusion Gene - ACTB::FOSB Fusion Gene - Actin Beta/FosB Proto-Oncogene Fusion Gene - Actin Beta::FosB Proto-Oncogene Fusion Gene