Plerixafor

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.

**Synonyms:** - 1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane - AMD 3100 - AMD 3100 - AMD-3100 - AMD3100 - JM-3100 - Mozobil - Mozobil - PLERIXAFOR - SDZ SID 791 - plerixafor