Activating RAS Q61X

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the amino acid residue at position 61 of a RAS family (HRAS, KRAS or NRAS) protein where the glutamine is replaced by another amino acid and the encoded GTPase is resistant to GTP hydrolysis, which results in constitutive activation of its activity and downstream pathways.

**Synonyms:** - Activating RAS Family Codon 61 Mutation - Activating RAS Family Gln61 Mutation - Activating RAS Family Q61 Mutation - Activating RAS Gln61 Mutation - Activating RAS Gln61Xxx - Activating RAS Q61 Mutation - Activating RAS Q61 Mutation - Activating RASQ61 Mutation