MLH1 Protein

**Semantic type:** Amino Acid, Peptide, or Protein|Biologically Active Substance

**Definition:** MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3. MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex. MLH1 is homologous to MutL, which hydrolyzes ATP. (from OMIM 120436 and NCI)

**Synonyms:** - MLH1 Gene Product - MUTL Protein Homolog 1 - Mismatch DNA Repair Protein MLH1 - hMLH1 Protein