MIR143/NOTCH3 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(5;19)(q32;p13) that fuses exon 1 of the MIR143 gene to exon 29 of the NOTCH3 gene. This rearrangement may result in overexpression of the NOTCH intracellular domain (NICD) of neurogenic locus notch homolog protein 3 and is associated with benign and malignant glomus tumors.

**Synonyms:** - MIR143-NOTCH3 Fusion Gene - MIR143::NOTCH3 Fusion Gene - MicroRNA 143-Notch 3 Fusion Gene - MicroRNA 143/Notch 3 Fusion Gene