SORT1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SORT1 wild-type allele is located in the vicinity of 1p13.3 and is approximately 88 kb in length. This allele, which encodes sortilin protein, plays a role in protein trafficking and neuroactive peptide-dependent signaling. The minor allele for a noncoding polymorphism in the promoter for this gene creates a CCAAT/enhancer binding protein transcription factor binding site and may result in increased hepatic expression of the encoded protein, decreased circulating cholesterol and decreased risk for myocardial infarction.

**Synonyms:** - Gp95 - LDL-C QTL6 - LDLCQ6 - Low Density Lipoprotein Cholesterol Level QTL6 Gene - Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 Gene - NT3 - NTR3 - Neurotensin Receptor, 100-kD Gene - Sortilin 1 wt Allele