Partially HLA-matched AdV/CMV/EBV/BKV-specific Allogeneic T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of partially human leukocyte antigen (HLA)-matched allogeneic cytotoxic T-lymphocytes (CTLs) that are specifically reactive to the four viruses adenovirus (AdV), cytomegalovirus (CMV), Epstein-Barr virus (EBV) and human polyomavirus type I (BKV), with potential antiviral activity. Upon infusion of the partially HLA-matched AdV/CMV/EBV/BKV-specific allogeneic T-lymphocytes upon allogeneic hematopoietic stem cell transplantation (HSCT) in an immunodeficient recipient, these CTLs may kill AdV, CMV, EBV and/or BKV-infected cells, and may prevent or reduce the severity of viral infections by these pathogens.

**Synonyms:** - Allogeneic AdV/CMV/EBV/BKV VSTs - Allogeneic AdV/CMV/EBV/BKV Virus-specific T Cells - HLA-matched Multivirus-specific Cytotoxic T-Lymphocytes - HLA-matched VSTs