Personalized Neoantigen Plasmid DNA Melanoma Vaccine EVX-02

**Semantic type:** Immunologic Factor|Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A plasmid DNA melanoma vaccine composed of DNA plasmid encoding multiple, melanoma patient-specific neoepitopes, which are highly immunogenic tumor associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon intramuscular (IM) administration of personalized neoantigen plasmid DNA melanoma vaccine EVX-02, the plasmid DNA is taken up by antigen-presenting cells (APCs) and the expressed neoepitopes induce cytotoxic T-lymphocyte (CTL)-mediated immune responses against melanoma cells expressing these specific TAAs.

**Synonyms:** - EVX 02 - EVX-02 - EVX02 - Melanoma Vaccine EVX-02 - Personalized Melanoma Vaccine EVX-02 - Plasmid DNA Melanoma Vaccine EVX-02