Gallium Ga 68 AIP-301

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of AIP-301, a molecule targeting the tumor-associated antigen (TAA) epidermal growth factor receptor 2 (HER2, EGFR2, ERBB2), that is linked to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 AIP-301, the AIP-301 moiety targets and binds to HER2-expressing tumor cells. This facilitates both the detection of HER2-expressing tumor cells and the assessment of responses to AIP-303 and other HER2-targeted chemotherapeutic agents during PET/CT. HER2, a tyrosine kinase, is overexpressed on the cell surfaces of various tumor cell types.

**Synonyms:** - 68Ga-AIP 301 - 68Ga-AIP-301 - 68Ga-AIP301 - Gallium Ga 68 AIP 301 - Gallium Ga 68 AIP301