Ciltistotug

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A humanized , immunoglobulin G2 (IgG2) agonistic antibody targeting the immune checkpoint human B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, ciltistotug targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation of the immune system.

**Synonyms:** - Anti-CD40 Agonist Antibody YH003 - CILTISTOTUG - YH 003 - YH-003 - YH003