Anti-MSLN CAR-T Cells LCAR-M23

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the human tumor-associated antigen (TAA) mesothelin (MSLN), with potential immunomodulating and antineoplastic activities. Upon administration, the anti-MSLN CAR-T cells LCAR-M23 specifically target and kill MSLN-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.

**Synonyms:** - Anti-mesothelin CAR T-cells LCAR-M23 - LCAR M23 - LCAR-M23 - LCARM23 - Mesothelin-targeting CAR T Cells LCAR-M23