Autologous Neoantigen-specific T-lymphocytes GEN-011

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous, personalized, immunogenic and tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. Tumor-specific neoantigen targets of autologous CD4+ and/or CD8+ T-cells are identified and T-cells that target immunogenic and stimulatory neoantigens are expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes GEN-011 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.

**Synonyms:** - Autologous Immunogenic Neoantigen-specific T-cells GEN-011 - Autologous Neoantigen-targeting T-cells GEN-011 - GEN 011 - GEN-011 - GEN011