TRAF3IP2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human TRAF3IP2 wild-type allele is located in the vicinity of 6q21 and is approximately 52 kb in length. This allele, which encodes E3 ubiquitin ligase TRAF3IP2 protein, plays a role in both protein polyubiquitination and the activation of nuclear factor kappa-B and mitogen-activated protein kinase 8. Polymorphism in the gene is associated with increased susceptibility for psoriasis and homozygous mutation in the gene is associated with familial chronic mucocutaneous candidiasis-8.

**Synonyms:** - ACT1 - C6orf2 - C6orf4 - C6orf5 - C6orf6 - CANDF8 - CIKS - Chromosome 6 Open Reading Frame 2 Gene - Chromosome 6 Open Reading Frame 4 Gene - Chromosome 6 Open Reading Frame 5 Gene - Chromosome 6 Open Reading Frame 6 Gene - DKFZP586G0522 - PSORS13 - TRAF3 Interacting Protein 2 wt Allele