E3 Ubiquitin Ligase TRAF3IP2

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** E3 ubiquitin ligase TRAF3IP2 (574 aa, ~65 kDa) is encoded by the human TRAF3IP2 gene. This protein is involved in the regulation of signal transduction downstream of tumor necrosis factor receptors and polyubiquitination of target proteins.

**Synonyms:** - Adapter Protein CIKS - Connection to I-Kappa-B Kinase and Stress-Activated Protein Kinase - Connection to IKK and SAPK/JNK - E3 Ubiquitin-Protein Ligase CIKS - EC 2.3.2.27 - NFkB-Activating Protein ACT1 - Nuclear Factor Kappa-B Activator 1 - Nuclear Factor NF-Kappa-B Activator 1 - TRAF3 Interacting Protein 2 - TRAF3-Interacting Protein 2 - TRAF3IP2