GEM 132

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A 20-mer mixed backbone oligonucleotide exhibiting anti-viral activity. GEM-132 is comprised of a strand of synthetic DNA with a modified RNA at each end (2-O-methylribonucleosides at the two 3- and four 5-terminal nucleotides) which is complementary to the intron-exon boundary of the UL35 and UL37 pre-mRNA transcripts of human cytomegalovirus. (NCI)

**Synonyms:** - Gene Expression Modulator 132