Autologous Anti-CD30 CAR T Cells HSP-CAR30

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the CD30 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD30 CAR T cells HSP-CAR30 specifically recognize and bind to CD30-expressing tumor cells, resulting in tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is transiently expressed on activated lymphocytes and is constitutively expressed in hematologic malignancies.

**Synonyms:** - Autologous Anti-CD30 CAR-T Cells HSP-CAR30 - Autologous CD30-targeting CAR T-cells HSP-CAR30 - HSP CAR30 - HSP-CAR30 - HSPCAR30