Muzastotug

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A human monoclonal antibody with a masked antibody binding site directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration and the activation of the antibody binding site in the tumor microenvironment (TME), muzastotug targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.

**Synonyms:** - ADG 126 - ADG-126 - ADG126 - Anti-CTLA-4 Monoclonal Antibody ADG126 - Anti-CTLA-4 SAFEbody ADG126 - MUZASTOTUG